| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2038871 | Cell | 2006 | 12 Pages |
Abstract
Cholesterol is an essential component of animal cell membranes, and its concentration is tightly controlled by a feedback system that operates at transcriptional and posttranscriptional levels. Here, we discuss recent advances that explain how cells employ an ensemble of membrane-embedded proteins to monitor sterol concentrations and adjust sterol synthesis and uptake.
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Authors
Joseph L. Goldstein, Russell A. DeBose-Boyd, Michael S. Brown,