| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2040789 | CMGH Cellular and Molecular Gastroenterology and Hepatology | 2016 | 30 Pages |
Abstract
UPR-resistant, internal ribosome entry site-driven netrin-1 translation leads to the inhibition of uncoordinated phenotype-5/death-associated protein kinase 1-mediated apoptosis in the hepatic context during UPR, a hallmark of chronic liver disease.
Keywords
PBSeukaryotic translation initiation factor 2ADependence receptorVR1netrinNMIAUNC5RlucLSLtunicamycinIRESDAPKATF6eIF2αUPRDMSqRT-PCRDTTmRNAPP2AFLucHCCIRE1αmessenger RNASmall interfering RNAsiRNAterminal deoxynucleotidyl transferase–mediated deoxyuridine triphosphate nick-end labelingTranslationTUNELdimethyl sulfatedithiothreitolinternal ribosome entry siteCMVcytomegalovirusendoplasmic reticulumactivated transcription factor 6Firefly luciferasePhosphate-buffered salineUTR یا untranslated regions untranslated regionHepatocyteHBVHCVHepatitis C virusquantitative reverse-transcription polymerase chain reactionhepatitis B virusUnfolded protein responseprotein phosphatase 2Adeath-associated protein kinasePERKHepatocellular carcinomaVanilloid receptor 1
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Authors
Thomas Lahlali, Marie-Laure Plissonnier, Cristina Romero-López, Maud Michelet, Benjamin Ducarouge, Alfredo Berzal-Herranz, Fabien Zoulim, Patrick Mehlen, Romain Parent,