Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2040951 | CMGH Cellular and Molecular Gastroenterology and Hepatology | 2015 | 11 Pages |
Abstract
Oxidized LDL is a novel predictor of SVR after interferon-based therapy and may explain the previously observed association of LDL with SVR. Rather than being a marker of activated antiviral defenses it may improve chances of SVR by limiting spread of infection to naive cells through the cell-to-cell route.
Keywords
PBSRFPoxLDLpegylated interferon αHCVccSR-BIRBVPEG-IFNNLSDAADMEMSVRDTTROCDulbecco’s modified Eagle mediumdithiothreitolRibavirinnuclear localization signalOxidized low-density lipoproteinLow-density lipoproteinLDLPhosphate-buffered salineHepatitis C virusHCVhydrochlorideSustained virologic responsered fluorescent proteinCell-to-cell spreadreceiver operating characteristic
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Authors
Philipp Solbach, Sandra Westhaus, Maximilian Deest, Eva Herrmann, Thomas Berg, Michael P. Manns, Sandra Ciesek, Christoph Sarrazin, Thomas von Hahn,