| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2040954 | CMGH Cellular and Molecular Gastroenterology and Hepatology | 2015 | 18 Pages |
Abstract
Expression of a viral antigen by hepatocytes can induce a state of peripheral tolerance mediated by regulatory TÂ cells that can lead to the establishment of a chronic viral infection. Strategies targeting regulatory T cells in patients chronically infected with hepatotropic viruses could represent a promising approach to restore functional antiviral immunity and clear infection.
Keywords
LILAPCTTRTregALTCFSEBTLALCMVTCrP14PD-L1CTLRAGPD-1ARMB and T lymphocyte attenuatorFOXP3FACStransthyretinliver-infiltrating lymphocytesenzyme-linked immunoassayAlanine aminotransferaseallophycocyanininterferonIFNinterleukinELISATolerancetumor necrosis factor-αforkhead box P3intraperitonealIntravenousRegulatory T cellChronic infectionTNF-αphycoerythrinfluorescence-activated cell sortercytotoxic T lymphocyteProgrammed death-1NucleoproteinhepatitisHBVHepatitis C virusHCVplaque-forming unitshepatitis B virusLymphocytic choriomeningitis viruspfuRecombination-Activating Genecarboxyfluorescein diacetate succinimidyl esterGlycoproteinT-cell receptor
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Authors
Pascal Lapierre, Valérie Janelle, Marie-Pierre Langlois, Esther Tarrab, Tania Charpentier, Alain Lamarre,