Thermodynamics of the solubility of lomefloxacin in methanol, ethanol, 1-propanol, 2-propanol, acetone, and chloroform from 293.15 to 323.15 K

The solubilities of lomefloxacin in methanol, ethanol, 1-propanol, 2-propanol, acetone, and chloroform have been determined from 293.15 to 323.15 K by a static equilibrium method. The experimental data were correlated with the modified Apelblat equation. The positive ΔsolH and ΔsolS for each system revealed that lomefloxacin being dissolved in each solvent was an entropy-driven process.

► We experimentally determined the solubilities of lomefloxacin in methanol, ethanol, 1-propanol, 2-propanol, acetone, and chloroform from 293.15 to 323.15 K by a static equilibrium method. ► The experimental data were correlated with the modified Apelblat equation. ► The calculated results show good agreement with the experimental data. ► The molar enthalpies and the molar entropies of dissolution in every system have been calculated by the fundamental thermodynamic relation, respectively.