Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2053994 | International Journal of Medical Microbiology | 2015 | 7 Pages |
Abstract
The integrase is sufficient for the integration and excision of the small variant into and from the DNA backbone, respectively. Thus, the element may be suitable to be used as a genetic tool in F. tularensis research. Furthermore, we identified the tRNAVal gene of Francisella as an integration site for GIs. Genomic island FphGI-1 was identified in Francisella philomiragia ATCC 25016. We were not able to detect the episomal form of this GI, probably due to a mutated attR site. However, we could demonstrate that integrative GIs are present in Francisella and that they may allow horizontal gene transfer between different Francisella species.
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Authors
Kerstin Rydzewski, Hana Tlapák, Indra P. Niehaus, Piotr W. Dabrowski, Roland Grunow, Klaus Heuner,