| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2065090 | Toxicon | 2009 | 5 Pages |
Abstract
Azaspiracid-2 was isolated from a marine sponge Echinoclathria sp. collected off Amami-Oshima as the predominant cytotoxic constituent. A combination of HPLC using ODS, GS320, and Phenylhexyl stationary phases permitted the purification without using acid or inorganic additives in the mobile phase. Azaspiracid-2 exhibited potent cytotoxicity against P388 cells with an IC50 value of 0.72 ng/mL and caused S phase arrest on the cell cycle.
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Authors
Reiko Ueoka, Akihiro Ito, Miho Izumikawa, Satoko Maeda, Motoki Takagi, Kazuo Shin-ya, Minoru Yoshida, Rob. W.M. van Soest, Shigeki Matsunaga,