Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2065900 | Toxicon | 2006 | 9 Pages |
Abstract
A cis-isomer of a C8-diol ester of okadaic acid (1) was isolated during large-scale purification of pectenotoxins (PTXs) from extracts of Dinophysis acuta collected from the west coast of South Island, New Zealand. The compound was identified by NMR spectroscopic and liquid chromatography-mass spectrometry (LC-MS) studies, and is the first reported cis-isomer of an okadaic acid C8-diol-ester identified in Dinophysis. The more abundant trans-C8-diol ester of okadaic acid (2) isolated from the same Dinophysis extract was rapidly hydrolyzed to okadaic acid in vitro by the supernatant from green-lipped mussel hepatopancreas.
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Authors
Christopher O. Miles, Alistair L. Wilkins, Allan D. Hawkes, Dwayne J. Jensen, Janine M. Cooney, Kristofer Larsen, Dirk Petersen, Frode Rise, Veronica Beuzenberg, A. Lincoln MacKenzie,