The neutralizing capacity of Androctonus crassicauda antivenom against Mesobuthus eupeus scorpion venom

The median lethal dose of M. eupeus and A. crassicauda scorpion venoms were found to be 0.18 mg/kg, 15.45 μg/kg by i.c.v injection route. The antivenom showed neutralization effect against the venoms of M. eupeus. One milliliter of A. crassicauda antivenom neutralizes 464LD50 of M. eupeus and 940LD50A. crassicauda venom on mice. Western blotting demonstrated immunologic reaction with the venoms. The monovalent antivenom has immunoactivity and neutralizing capacity to the scorpion venoms. This study indicates that the antivenom produced by Refik Saydam Hygiene Center could be used for the treatment of M. eupeus stings in Turkey.