Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2067161 | Cell Biology International | 2009 | 8 Pages |
Abstract
Myosin X (Myo X), an unconventional myosin with a tail homology 4-band 4.1/ezrin/radixin/moesin (MyTH4-FERM) tail, is expressed ubiquitously in various mammalian tissues. In addition to the full-length Myo X (Myo X FL), a headless form is synthesized in the brain. So far, little is known about the function of this motor-less Myo X. In this study, the role of the headless Myo X was investigated in immortalized gonadotropin-releasing hormone (GnRH) neuronal cells, NLT. NLT cells overexpressing the headless Myo X formed fewer focal adhesions and spread more slowly than the wild-type NLT cells and GFP-expressing NLT cells. In chemomigration assays, the NLT cells overexpressing the headless Myo X migrated shorter distances and had fewer migratory cells compared with the control NLT cells.
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Authors
Jun-Jie Wang, Xiu-Qing Fu, Yu-Guang Guo, Lin Yuan, Qian-Qian Gao, Hua-Li Yu, Heng-Liang Shi, Xing-Zhi Wang, Wen-Cheng Xiong, Xiao-Juan Zhu,