Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2067807 | Cell Biology International | 2007 | 6 Pages |
Abstract
Upon antigenic stimulation, CD1d-restricted NKT cells quickly secrete large amounts of cytokines. This prompt response demonstrates that CD1d-restricted NKT cells may potentially prove to be useful therapeutic agents for the treatment of many diseases. Despite the clinical importance of CD1d-restricted NKT cells, the regulating mechanisms of this unique T cell population remain to be defined. We found murine LAG-3 is inducible on CD1d-restricted NKT cells as the result of a variety of stimulants such as concanavalin A (con A) and anti-CD3. Also, antigen-specific CD1d stimulation can elicit LAG-3 in CD1d-restricted NKT cells. Moreover, ectopic LAG-3 expression on CD1d-restricted NKT cells results in cell cycle arrest in the S phase. These results show that LAG-3 signaling on activated CD1d-restricted NKT cells may down-modulate NKT cell proliferation.
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Authors
Hyun-Jung Byun, Woon-Won Jung, Dong-Sup Lee, Sanghee Kim, Sang Joon Kim, Chung-Gyu Park, Hee Yong Chung, Taehoon Chun,