Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2068781 | Mitochondrion | 2011 | 7 Pages |
Abstract
Cancer development involves multiple genetic changes, which can occur in tumor suppressor genes and lead to loss of function in a recessive manner. Recent findings have identified a novel tumor suppressor gene named GRIM-19. Similar to what has been observed for other known tumor suppressor proteins such as p53, GRIM-19 gene mutations and loss of protein expression have been observed in several tumor types. In this review, we perform a detailed description on the current understanding of GRIM-19 function in carcinogenesis.
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Authors
Severina Moreira, Marcelo Correia, Paula Soares, Valdemar Máximo,