Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2069011 | Mitochondrion | 2010 | 7 Pages |
Abstract
Although α-mangostin prevents from toxicity associated to oxidative stress, it also promotes apoptotic cell death in cancer cells. Such effects have been associated with mitochondrial membrane depolarization and cytochrome c release. Therefore, the aim of this work was to analyze the potentially harmful effect of this natural compound on relevant parameters of mitochondrial function from normal tissue. Our results showed that α-mangostin protected mitochondria from peroxidative damage, but at high concentration, it acted as an uncoupler, reduced dramatically ADP-stimulated respiration and inhibited the activity of respiratory complex IV, making mitochondria prone to permeability transition, which is a mitochondrial player on cell fate.
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Authors
E. Martínez-Abundis, N. García, F. Correa, S. Hernández-Reséndiz, J. Pedraza-Chaverri, C. Zazueta,