Article ID Journal Published Year Pages File Type
2069226 Mitochondrion 2008 11 Pages PDF
Abstract

We studied whether mitochondrial functions and Ca2+ metabolism were altered in Wistar Kyoto normotensive (WKY) and spontaneous hypertensive rats (SHR). Ca2+ uptake was decreased in SHR compared to WKY rats. Accumulation of Ca2+ was more efficient in WKY than in SHR rats. mΔΨ was lower in SHR compared to WKY rats. Basal complex IV activity was higher in SHR than WKY rats, whereas basal l-citrulline production, an indicator of nitric oxide synthesis, was decreased in SHR and dependent on Ca2+ concentration (p < 0.05). Impact of Ca2+ was counteracted by EGTA. These data show an age-dependent decreased mitochondrial functions in brain mitochondria during hypertension.

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