Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2069418 | Mitochondrion | 2007 | 5 Pages |
Abstract
Tanshinone IIA exerts anti-inflammatory effects and influences electron transfer reaction in mitochondria. In the present study, we demonstrated that tanshinone IIA increased intracellular production of reactive oxygen species (ROS), which in turn induces heme oxygenase-1 (HO-1) expression in RAW 264.7 macrophages. Tanshinone IIA inhibited COX-2 and iNOS expression in lipopolysaccharide-activated RAW 264.7 macrophages. Inhibition of HO-1 or scavenging of CO significantly reversed the inhibition of LPS-stimulated nitrite accumulation by tanshinone IIA, suggesting a novel role of HO-1 in the anti-inflammatory effect of tanshinone IIA.
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Authors
Tso-Hsiao Chen, Yu-Tern Hsu, Cheng-Hsien Chen, Shu-Hwei Kao, Horng-Mo Lee,