Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2069632 | Mitochondrion | 2007 | 26 Pages |
Abstract
In mitochondria, most Coenzyme Q is free in the lipid bilayer; the question as to whether tightly bound, non-exchangeable Coenzyme Q molecules exist in mitochondrial complexes is still an open question.We review the mechanism of inter-complex electron transfer mediated by ubiquinone and discuss the kinetic consequences of the supramolecular organization of the respiratory complexes (randomly dispersed vs. super-complexes) in terms of Coenzyme Q pool behavior vs. metabolic channeling, respectively, both in physiological and in some pathological conditions. As an example of intra-complex electron transfer, we discuss in particular Complex I, a topic that is still under active investigation.
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Authors
Giorgio Lenaz, Romana Fato, Gabriella Formiggini, Maria Luisa Genova,