Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2070611 | Progress in Biophysics and Molecular Biology | 2010 | 6 Pages |
Abstract
Complex signal-transduction cascades are known to be involved in regulating cardiomyocyte function, death and survival during acute cardiac ischemia-reperfusion process, but detailed survival signalling pathways are not clear. This review presents and discusses the recent findings bearing upon the evidence on the cardioprotective effect of sphingosine-1-phosphate (S1P) and bradykinin in acute cardiac ischemia-reperfusion and underlying signalling mechanisms, particularly, through activation of P21 activated kinase.
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Authors
Emmanuel Eroume A. Egom, Yunbo Ke, R. John Solaro, Ming Lei,