Carbon nanotubes as vaccine scaffolds

Carbon nanotubes display characteristics that are potentially useful in their development as scaffolds for vaccine compositions. These features include stability in vivo, lack of intrinsic immunogenicity, low toxicity, and the ability to be appended with multiple copies of antigens. In addition, the particulate nature of carbon nanotubes and their unusual properties of rapid entry into antigen-presenting cells, such as dendritic cells, make them especially useful as carriers of antigens. Early attempts demonstrating carbon nanotube-based vaccines can be used in both infectious disease settings and cancer are promising.

Graphical abstractDepiction of single-wall carbon nanotubes appended with multiple antigens and mixed with an immunological adjuvant, thereby constituting a vaccine.Figure optionsDownload full-size imageDownload high-quality image (121 K)Download as PowerPoint slide