Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2071189 | Advanced Drug Delivery Reviews | 2012 | 8 Pages |
Abstract
Oral vaccine has been considered to be a prospective vaccine against many pathogens especially invading across gastrointestinal tracts. One key element of oral vaccine is targeting efficient delivery of antigen to gut-associated lymphoid tissue (GALT), the inductive site in the intestine where antigen-specific immune responses are initiated. Various chemical and biological antigen delivery systems have been developed and some are in clinical trials. In this review, we describe the immunological features of GALT and the current status of antigen delivery system candidates for successful oral vaccine.
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Authors
Jun Kunisawa, Yosuke Kurashima, Hiroshi Kiyono,