Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2071256 | Advanced Drug Delivery Reviews | 2011 | 15 Pages |
Abstract
Nanoparticles bring many benefits to pulmonary drug delivery applications, especially for systemic delivery and drugs with poor solubility. They have recently been explored in pressurized metered dose inhaler, nebulizer, and dry powder inhaler applications, mostly in polymeric forms. This article presents a review of processes that have been used to generate pure (non polymeric) drug nanoparticles, methods for characterizing the particles/formulations, their in-vitro and in-vivo performances, and the fate of inhaled nanoparticles.
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Authors
Jian Zhang, Libo Wu, Hak-Kim Chan, Wiwik Watanabe,