| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2071371 | Advanced Drug Delivery Reviews | 2011 | 8 Pages |
The development of substitutes for the human trachea or its bronchial tree represents a niche application in the rapidly advancing scientific field of Regenerative Medicine. Despite a comparatively small research foundation in the field of tracheo-bronchial bioengineering, four different approaches have already been translated into clinical settings and applied in patients. This can be attributed to the lack of established treatment options for a small group of patients with extensive major airway disease. In this review, the clinical background and tissue-specific basics of tracheo-bronchial bioengineering will be evaluated. Focusing on the clinical applications of bioengineered tracheal tissues, a “top–down” or “bedside-to-bench” analysis is performed in order to guide future basic and clinical research activities for airway bioengineering.
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