Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2071703 | Advanced Drug Delivery Reviews | 2009 | 7 Pages |
Abstract
Human ATP-binding cassette (ABC) transporter ABCG2 (BCRP/MXR/ABCP) is a plasma membrane protein carrying intra- and inter-molecular disulfide bonds and an N-linked glycan. Both disulfide bond formation and N-glycosylation are critical check points determining the stability and degradation fate of ABCG2 protein in the endoplasmic reticulum (ER). Misfolded ABCG2 protein without those post-translational modifications is removed from the ER by retrotranslocation to the cytosol compartment, ubiquitination by ubiquitin ligase, and finally degradation by proteasomes. Certain non-synonymous SNP variants of ABCG2 undergo such ER-associated degradation (ERAD).
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Authors
Kanako Wakabayashi-Nakao, Ai Tamura, Tomoka Furukawa, Hiroshi Nakagawa, Toshihisa Ishikawa,