Article ID Journal Published Year Pages File Type
2071897 Advanced Drug Delivery Reviews 2008 14 Pages PDF
Abstract

This article reviews the basic physics of ultrasound generation, acoustic field, and both inertial and non-inertial acoustic cavitation in the context of localized gene and drug delivery as well as non-linear oscillation of an encapsulated microbubble and its associated microstreaming and radiation force generated by ultrasound. The ultrasound thermal and mechanical bioeffects and relevant safety issues for in vivo applications are also discussed.

Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Biotechnology
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