Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2072122 | Advanced Drug Delivery Reviews | 2013 | 7 Pages |
Abstract
Statistical modeling coupled with bioinformatics is commonly used for drug discovery. Although there exist many approaches for single target based drug design and target inference, recent years have seen a paradigm shift to system-level pharmacological research. Pathway analysis of genomics data represents one promising direction for computational inference of drug targets. This article aims at providing a comprehensive review on the evolving issues in this field, covering methodological developments, their pros and cons, as well as future research directions.
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Authors
Haisu Ma, Hongyu Zhao,