Article ID Journal Published Year Pages File Type
2072158 Advanced Drug Delivery Reviews 2013 9 Pages PDF
Abstract

The EPR effect results from the extravasation of macromolecules or nanoparticles through tumor blood vessels. We here provide a historical review of the EPR effect, including its features, vascular mediators found in both cancer and inflamed tissue. In addition, architectural and physiological differences of tumor blood vessels vs that of normal tissue are commented. Furthermore, methods of augmentation of the EPR effect are described, that result in better tumor delivery and improved therapeutic effect, where nitroglycerin, angiotensin I-converting enzyme (ACE) inhibitor, or angiotensin II-induced hypertension are employed. Consequently, better therapeutic effect and reduced systemic toxicity are generally observed. Obviously, the EPR effect based delivery of nanoprobes are also useful for tumor-selective imaging agents with using fluorescent or radio nuclei in nanoprobes. We also commented a key difference between passive tumor targeting and the EPR effect in tumors, particularly as related to drug retention in tumors: passive targeting of low-molecular-weight X-ray contrast agents involves a retention period of less than a few minutes, whereas the EPR effect of nanoparticles involves a prolonged retention time—days to weeks.

Graphical abstractColor images in (A) using low molecular weight fluorescent dye [rhodamine B] is compared with that of high molecular weight in (B) using albumin conjugated with tetraetylrhodamine (67 kDa), fluorescent nanoprobe. The latter (B) shows distinct fluorescent tumor image in vivo, reflecting tumor selective accumulation of nanoprobes based on the EPR. Tumor (S-180) is located at both left and right dorsal skin showing intense fluorescence. In contrast no tumor selective drug uptake is seen for the low molecular weight dye, free Rhodamine B in (A).Figure optionsDownload full-size imageDownload high-quality image (178 K)Download as PowerPoint slide

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