Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2075983 | Biosystems | 2013 | 8 Pages |
Abstract
In vitro pattern classification has been highlighted as an important future application of DNA computing. Previous work has demonstrated the feasibility of linear classifiers using DNA-based molecular computing. However, complex tasks require non-linear classification capability. Here we design a molecular beacon that can interact with multiple targets and experimentally shows that its fluorescent signals form a complex radial-basis function, enabling it to be used as a building block for non-linear molecular classification in vitro. The proposed method was successfully applied to solving artificial and real-world classification problems: XOR and microRNA expression patterns.
Keywords
Related Topics
Physical Sciences and Engineering
Mathematics
Modelling and Simulation
Authors
In-Hee Lee, Seung Hwan Lee, Tai Hyun Park, Byoung-Tak Zhang,