Non-Gaussian noise-optimized intracellular cytosolic calcium oscillations

We have numerically studied the effect of a particular kind of non-Gaussian colored noise (NGN), characterized by the deviation q from Gaussian noise (q = 1), on intracellular cytosolic calcium (Ca2+) oscillations. It is found that, as q is increased, the Ca2+ oscillation regularity increases and reaches a best performance at an optimal q, and then decreases with further increasing q, which represents the occurrence of coherence resonance, i.e., the most regular Ca2+ oscillations. Similar phenomena occur for different values of noise intensity and correlation time of the NGN. This phenomenon of deviation-optimized Ca2+ oscillations show that, external non-Gaussian noises of different types can enhance and even optimize the intracellular Ca2+ oscillations. This result provides new insights into the constructive roles and potential applications of non-Gaussian noises in intracellular cytosolic Ca2+ oscillations.