Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2076294 | Biosystems | 2010 | 7 Pages |
Abstract
Hysteretic behavior is found experimentally in the transmembrane potential at low extracellular potassium in mouse lumbrical muscle cells. Adding isoprenaline to the external medium eliminates the bistable, hysteretic region. The system can be modeled mathematically and understood analytically with and without isoprenaline. Inward rectifying potassium channels appear to be essential for the bistability. Relations are derived to express the dimensions of the bistable area in terms of system parameters. The selective advantage and evolutionary origin of inward rectifying channels and hysteretic behavior is discussed.
Related Topics
Physical Sciences and Engineering
Mathematics
Modelling and Simulation
Authors
Jill Gallaher, Martin Bier, Jan Siegenbeek van Heukelom,