Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2076568 | Biosystems | 2007 | 11 Pages |
Abstract
Experimentally, some so-called “inactive” components were shown to have a residual activity. This has been mostly ignored in mathematical models. Our analysis reveals that bistability is only mildly affected in the case of zero-order or inhibitor ultrasensitivity. However, the case where bistability is achieved by cooperative ultrasensitivity is severely affected by this perturbation.
Related Topics
Physical Sciences and Engineering
Mathematics
Modelling and Simulation
Authors
Thomas EiÃing, Steffen Waldherr, Frank Allgöwer, Peter Scheurich, Eric Bullinger,