| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2076747 | Biosystems | 2008 | 6 Pages |
Abstract
Telomere shortening provides a molecular basis for the Hayflick limit. Recent data suggest that telomere shortening also influence mitotic rate. We propose a stochastic growth model of this phenomena, assuming that cell division in each time interval is a random process which probability decreases linearly with telomere shortening.Computer simulations of the proposed stochastic telomere-regulated model provides good approximation of the qualitative growth of cultured human mesenchymal stem cells.
Related Topics
Physical Sciences and Engineering
Mathematics
Modelling and Simulation
Authors
R.D. Portugal, M.G.P. Land, B.F. Svaiter,