| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2076921 | Biosystems | 2006 | 7 Pages |
Abstract
A novel way of computational modeling by integrating compartmental neural techniques and detailed kinetic description of pharmacological modulation of transmitter-receptor interaction is offered as a method to test the electro-physiological and behavioral effects of potential drugs. Even more, an inverse method is suggested as a method for controlling a neural system to realize a prescribed temporal pattern. Generation and pharamcological modulation of theta rhythm in area CA1 of the hippocampus related to anxiety is analyzed. Integrative modeling might help to find positive allosteric modulators of α1 subunits as potential candidates for being selective anxyolitics.
Related Topics
Physical Sciences and Engineering
Mathematics
Modelling and Simulation
Authors
Tamás Kiss, Péter Ãrdi,