Article ID Journal Published Year Pages File Type
2077018 Biosystems 2006 9 Pages PDF
Abstract

Individual-based or agent-based models have proved useful in a variety of different biological contexts. This paper presents an agent-based model using a formal computational modelling approach to model a crucial biological system—the intracellular NF-κB signalling pathway. The pathway is vital to immune response regulation, and is fundamental to basic survival in a range of species. Alterations in pathway regulation underlie many diseases, including atherosclerosis and arthritis. Our modelling of individual molecules, receptors and genes provides a more comprehensive outline of regulatory network mechanisms than previously possible with equation-based approaches. The model has been validated with data obtained from single cell experimental analysis.

Related Topics
Physical Sciences and Engineering Mathematics Modelling and Simulation
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