| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2077725 | Cell Stem Cell | 2011 | 13 Pages |
SummaryThe transcription factor Sox2 maintains the pluripotency of early embryonic cells and regulates the formation of several epithelia during fetal development. Whether Sox2 continues to play a role in adult tissues remains largely unknown. We show here that Sox2 marks adult cells in several epithelial tissues where its expression has not previously been characterized, including the stomach, cervix, anus, testes, lens, and multiple glands. Genetic lineage tracing and transplantation experiments demonstrate that Sox2-expressing cells continuously give rise to mature cell types within these tissues, documenting their self-renewal and differentiation potentials. Consistent with these findings, ablation of Sox2+ cells in mice results in a disruption of epithelial tissue homeostasis and lethality. Developmental fate mapping reveals that Sox2+ adult stem cells originate from fetal Sox2+ tissue progenitors. Thus, our results identify Sox2 expression in numerous adult endodermal and ectodermal stem cell compartments, which are critical for normal tissue regeneration and survival.
Graphical AbstractFigure optionsDownload full-size imageDownload high-quality image (213 K)Download as PowerPoint slideHighlights► Stem cell factor Sox2 is expressed in multiple adult self-renewing epithelia ► Adult Sox2+ stem cells are derived from fetal Sox2+ progenitors ► Transplantation of Sox2+ testis cells restores spermatogenesis in infertile mice ► Ablation of adult Sox2+ cells disrupts tissue integrity and results in lethality
