Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2077862 | Cell Stem Cell | 2010 | 11 Pages |
SummaryNeural progenitor cells (NPCs) in the adult subventricular zone (SVZ) are associated with ependymal and vasculature niches, which regulate stem cell self-renewal and differentiation. Activated Type B stem cells and their progeny, the transit-amplifying type C cells, which express EGFR, are most highly associated with vascular cells, indicating that this niche supports lineage progression. Here, we show that proliferative SVZ progenitor cells home to endothelial cells in a stromal-derived factor 1 (SDF1)- and CXC chemokine receptor 4 (CXCR4)-dependent manner. We show that SDF1 strongly upregulates EGFR and α6 integrin in activated type B and type C cells, enhancing their activated state and their ability to bind laminin in the vascular niche. SDF1 increases the motility of type A neuroblasts, which migrate from the SVZ toward the olfactory bulb. Thus, differential responses to SDF1 can regulate progenitor cell occupancy of and exit from the adult SVZ vascular niche.
► Neural stem cells home to the vascular niche in an SDF1/CXCR4-dependent manner ► Different progenitor populations show different responses to SDF1 ► SDF1 upregulates integrin α6 and EGFR in distinct progenitor populations