Antibacterial Activity and Property of the Fermentation Product of Marine Streptomyces sp. GB-2

Marine Streptomyces GB-2, isolated from marine samples collected from the intel tidal zone of Lianyungang, is found to produce antibacterial substance which has exhibited significant inhibitory effects on 11 Gram-positive bacteria and 4 Gram-negative bacteria. The antibacterial substance was proved to be neutral and water-soluble according to paper chromatogram analysis, whose production was significantly associated with artificial seawater. The results of stability studies of the fermentation broth of Streptomyces GB-2 showed that it was very stable at pH1 and pH12 under 121°C and had only little change after ultraviolet treatment. The potential use of substance produced by strain GB-2 in bio-control, food, and medical application was predicted.