| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2078910 | Chinese Journal of Biotechnology | 2008 | 6 Pages |
Abstract
Two LAL family regulatory genes, gdmRI and gdmRII, were identified in the geldanamycin biosynthetic gene cluster of Streptomyces hygroscopicus 17997. Disruption of the two regulatory genes resulted in absolute elimination of geldanamycin biosynthesis. The complementation experiments using a single wild-type gene could restore geldanamycin production. These results indicated that both gdmRI and gdmRII were positive regulatory genes of the geldanamycin biosynthesis.
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Authors
Weiqing He, Jian Lei, Yuying Liu, Yiguang Wang,