Article ID Journal Published Year Pages File Type
2079879 Drug Discovery Today 2016 12 Pages PDF
Abstract

•Dry powder coating is a promising one-step process to produce composite particles with improved functionalities.•Blend characterisation is based on the use of proper sampling techniques.•The selection of the right surface characterisation technique is essential to determine resultant functionality and optimisation of process parameters.

The production of composite particles using dry powder coating is a one-step, environmentally friendly, process for the fabrication of particles with targeted properties and favourable functionalities. Diverse functionalities, such flowability enhancement, content uniformity, and dissolution, can be developed from dry particle coating. In this review, we discuss the particle functionalities that can be tailored and the selection of characterisation techniques relevant to understanding their molecular basis. We address key features in the powder blend sampling process and explore the relevant characterisation techniques, focussing on the functionality delivered by dry coating and on surface profiling that explores the dynamics and surface characteristics of the composite blends.

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Life Sciences Biochemistry, Genetics and Molecular Biology Biotechnology
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