| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2080012 | Drug Discovery Today | 2013 | 8 Pages |
Ocular barriers and the poor water solubility of drug candidates present a number of problems for the development of ocular drug delivery systems. Recently, the emergence of lipid-based nanocarriers has provided a viable means of enhancing the bioavailability of ophthalmic formulations. A number of these formulations have been found to be clinically active and several others are currently undergoing clinical trials. In this review, the advantages of lipid-based nanocarriers as non-invasive topical ocular drug delivery systems are presented. Many systems, including emulsions, liposomes, cubosomes, niosomes and other lipid-based nanocarriers, are reviewed.
► Advantages of lipid-based nanocarriers as a topical ocular delivery system have been specified. ► Advances of lipid-based nanocarriers relevant to topical ocular drug delivery have been reviewed. ► Commercially available lipid-based nanocarriers have been reviewed.
