Catechins containing a galloyl moiety as potential anti-HIV-1 compounds

Catechins containing galloyl moieties are important natural antioxidant compounds. In this paper, we review the multiple mechanisms whereby catechins containing a galloyl moiety can target key proteins to inhibit sexual transmission of HIV-1, as well as HIV-1 fusion, HIV-1 reverse transcriptase, HIV-1 integrase and HIV-1 protease. Furthermore, catechins with a galloyl moiety can mediate host cell factors such as nitric oxide synthase, nuclear factor-κB and casein kinase II to inhibit HIV-1 infection. The most significant inhibitory effect is blocking gp120 binding to isolated human CD4+ T cells. The multiple mechanisms underlying the anti-HIV activity of galloyl-containing catechins predict that these catechins could be used as alternative therapies in the treatment of HIV infection.

► Mechanisms of action for catechins with galloyl moiety in the inhibition of HIV-1. ► Most significant inhibition as binding of gp120 to CD4+ T cells. ► Catechins with galloyl moiety are new alternative HIV-1 inhibitors. ► Catechins with galloyl moiety as natural, safe and inexpensive anti-HIV-1 drugs.