Therapeutic stratagems for vascular degenerative disorders of the posterior eye

In this review we discuss insights into therapeutic stratagems that can selectively target the choroid, retinal cells and vitreoretinal space for the treatment of vision-threatening vascular degenerative disorders of the posterior eye. Despite the relative success of these novel drugs, new problems related to its delivery remain. Systems carrying drugs to the target site, such as nanoparticles, liposomes, vectosomes, spanlastics, micelles, dendrimers and implants are also discussed. Further, we also consider drug penetration enhancement approaches along with cutting-edge strategies for regaining vision during vision-threatening vascular degenerative disorders of the eye. Finally, challenges, such as ocular or even systemic complications associated with use of prolonged therapies and future prospects, such as combination of approaches with multidisciplinary integration to optimize delivery to the posterior eye are also addressed.

► Therapeutic targets and drugs for vascular degenerative posterior eye disorders are reviewed. ► Novel carriers for targeted delivery their description and development stage are reviewed. ► Penetration enhancement approaches and devices for regaining vision are discussed. ► Challenges and future prospects for optimizing drug delivery to posterior eye is addressed.