Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2081716 | Drug Discovery Today: Disease Mechanisms | 2013 | 8 Pages |
Abstract
The primary cilium is a well-established target in the pathogenesis of numerous developmental and chronic disorders, and more recently is attracting interest as a structure relevant to cancer. Here we discuss mechanisms by which changes in cilia can contribute to the formation and growth of tumors. We emphasize the cancer-relevance of cilia-dependent signaling pathways and proteins, including mTOR, VHL, TSC, WNT, Aurora-A, NEDD9 and Hedgehog, and highlight the emerging role of ciliary dysfunction in renal cell carcinoma, medulloblastoma and breast cancer.
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Authors
Tamina Seeger-Nukpezah, Joy L. Little, Victoria Serzhanova, Erica A. Golemis,