Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2081741 | Drug Discovery Today: Disease Mechanisms | 2013 | 7 Pages |
Abstract
As rates of obesity soar in the Unites States and around the world, cancer attributed to obesity has emerged as a major threat to public health. The link between obesity and cancer can be attributed in part to the state of chronic inflammation, which develops in obesity. Acetyl-CoA production and protein acetylation patterns are highly sensitive to metabolic state and are significantly altered in obesity. In this article, we explore the potential role of nutrient-sensitive lysine acetylation in regulating inflammatory processes in obesity-linked cancer.
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Authors
Joyce V. Lee, Supriya A. Shah, Kathryn E. Wellen,