| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2081749 | Drug Discovery Today: Disease Mechanisms | 2012 | 7 Pages |
Abstract
Understanding the molecular changes that drive an acquired antiestrogen resistance phenotype is of major clinical relevance. Previous methodologies for addressing this question have taken a single gene/pathway approach and the resulting gains have been limited in terms of their clinical impact. Recent systems biology approaches allow for the integration of data from high throughput ‘-omics’ technologies. We highlight recent advances in the field of antiestrogen resistance with a focus on transcriptomics, proteomics and methylomics.
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Authors
Kerrie B Bouker, Yue Wang, Jianhua Xuan, Robert Clarke,