| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2081762 | Drug Discovery Today: Disease Mechanisms | 2011 | 7 Pages |
Abstract
Inappropriate activation of the Toll-IL-1R (TLR-IL-1R) signaling by commensal bacteria contributes to the pathogenesis of inflammatory bowel diseases and colitis-associated cancer. Recent studies have identified Single Immunoglobulin IL-1 Receptor Related molecule (SIGIRR) as a negative regulator of TLR-IL-1R signaling. It dampens intestinal inflammation and tumorigenesis in the colon. In this review, we will discuss the role of SIGIRR in different cell types and the mechanisms underlying its tumor suppressor function.
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Authors
Junjie Zhao, Jarod Zepp, Katarzyna Bulek, Xiaoxia Li,