| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2081782 | Drug Discovery Today: Disease Mechanisms | 2010 | 6 Pages |
Abstract
Oleoylethanolamide (OEA) is a lipid amide produced by enterocytes upon the absorption of dietary fat and participates in the induction of satiety. Through indirect pathways, probably depending on the local activation of peroxisome-proliferator-activated receptor-alpha and involving afferent vagus nerve fibers, OEA signal is transmitted to the brain-stem and the hypothalamus, where it stimulates the release of oxytocin from magnocellular neurons.OEA mechanism might, thus, provide a novel target for the design of therapies controlling appetite.
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Authors
Pasqua Dipasquale, Adele Romano, Silvia Cianci, Laura Righetti, Silvana Gaetani,