| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2081924 | Drug Discovery Today: Disease Mechanisms | 2006 | 7 Pages |
Abstract
The t(15;17) chromosomal translocation in acute promyelocytic leukemia (APL) results in the expression of the promyelocytic leukemia/retinoic acid receptor alpha (PML/RARα) fusion protein. This single gene rearrangement makes APL a unique malignancy because its oncogenic effect can be overcome by retinoic acid treatment. PML/RARα-induced leukemogenesis is a multistep process that extends beyond disruption of PML and RARα functions and requires cooperating events.
Section editor:John Tisdale – National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, USA
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Authors
Anna Laurenzana, Filippa Pettersson, Wilson H. Miller Jr,