| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2081957 | Drug Discovery Today: Disease Mechanisms | 2006 | 7 Pages |
Abstract
Interleukin (IL)-1 is a cytokine that plays a major role in inflammatory and autoimmune diseases. This cytokine initiates a wide range of proinflammatory cascades in many cell types. IL-1 and other members of the IL-1 superfamily are found in patients with many chronic inflammatory diseases. IL-1 drives both acute and chronic inflammation and its blockade has been shown to ameliorate disease in preclinical studies. This article reviews the role of IL-1 in chronic joint diseases, in particular models of rheumatoid arthritis (RA).
Section editors:Terry Delovitch – The John P. Robarts Research Institute, London, ON, CanadaDavid Scott – University of Maryland School of Medicine, Baltimore, MD, USA
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Authors
Leo A.B. Joosten, Wim B. van den Berg,