| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2081969 | Drug Discovery Today: Disease Mechanisms | 2006 | 8 Pages |
Abstract
HIV integrase (IN) is required for viral replication and a rationale target for antiretroviral therapies. Integrase inhibitors are potentially complementary to current treatments. This review focuses on the mechanisms of HIV integration. The roles of viral and cellular co-factors during preintegration complex (PIC) formation and integration are reviewed. The biochemical mechanisms of integration, integrase structures and approaches to inhibit integration are also described.
Section editors:William Bishai and Eric Nuermberger – John Hopkins School of Medicine, Baltimore, USA
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Authors
Christophe Marchand, Allison A. Johnson, Elena Semenova, Yves Pommier,