| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2082011 | Drug Discovery Today: Disease Mechanisms | 2006 | 5 Pages |
Abstract
Transforming growth factor-β (TGF-β) isoforms have profound roles in all forms of tissue repair and regeneration. In this review, we examine the role of TGF-βs in pulmonary fibrosis. We examine the possible sources of TGF-β, and how this factor signals via receptors through the Smad pathway. The link between inflammation and fibrosis is also examined. Understanding the role of TGF-β family members in fibrosis is vital to understanding how to develop novel treatments to slow or to reverse pulmonary fibrosis.
Section editors:Maria Belvisi – Imperial College School of Medicine, London, UKStuart Farrow – GlaxoSmithKline, Stevenage, UK
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Authors
Gail E.M. Martin, Kjetil Ask, Sarah E. Gilpin, Martin Kolb, Jack Gauldie,