| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2082067 | Drug Discovery Today: Disease Models | 2014 | 6 Pages |
Abstract
The past several decades of experimental investigation have revealed a rich complexity of cardiomyocyte Ca2+ dynamics. Integrating and decomposing these complex data now increasingly relies on mathematical modeling approaches. In reviewing the evolution and contributions of these cardiomyocyte models, we emphasize the importance of data-driven model parameterization, with iterative data exchange between experimentalists and modelers leading to novel generation of hypotheses.
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Authors
William E. Louch, Sander Land, Steven A. Niederer,